<i>Solanum nigrum</i> induces macrophage activation through TLR4-mediated activation of JNK and macrophage autophagy through TLR4-mediated activation of p38 and JNK
نویسندگان
چکیده
In this study, we investigated the effect of Solanum nigrum aerial parts (SNAP) on macrophage activation and autophagy in RAW264.7 cells. SNAP increased production immunostimulatory factors phagocytosis TLR4 inhibition blocked SNAP-mediated factors. addition, JNK reduced factors, was by inhibition. activated autophagy. p38 attenuated These findings indicate that may induce TLR4/JNK-mediated TLR4/p38 JNK-mediated
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ژورنال
عنوان ژورنال: Food and Agricultural Immunology
سال: 2022
ISSN: ['0954-0105', '1465-3443']
DOI: https://doi.org/10.1080/09540105.2022.2113507